BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Surveillance of Guillain-Barré Syndrome During the 2009–2010 H1
 N1 Influenza Vaccination Campaign in the United States - Dr Oliver Morgan\
 , Centers for Disease Control and Prevention\, US
DTSTART:20121123T130000Z
DTEND:20121123T140000Z
UID:TALK42005@talks.cam.ac.uk
CONTACT:Dr Simon Richard White
DESCRIPTION:Because of widespread distribution of the influenza A (H1N1) 2
 009 monovalent vaccine (pH1N1 vaccine) and the prior association between G
 uillain-Barré syndrome (GBS) and the 1976 H1N1 influenza vaccine\, enhanc
 ed surveillance was implemented to estimate the magnitude of any increased
  GBS risk following administration of pH1N1 vaccine. The authors conducted
  active\, population-based surveillance for incident cases of GBS among 45
  million persons residing at 10 Emerging Infections Program sites during O
 ctober 2009–May 2010\; GBS was defined according to published criteria. 
 The authors determined medical and vaccine history for GBS cases through m
 edical record review and patient interviews. The authors used vaccine cove
 rage data to estimate person-time exposed and unexposed to pH1N1 vaccine a
 nd calculated age- and sex-adjusted rate ratios comparing GBS incidence in
  these groups\, as well as age- and sex-adjusted numbers of excess GBS cas
 es. The authors received 411 reports of confirmed or probable GBS. The rat
 e of GBS immediately following pH1N1 vaccination was 57% higher than in pe
 rson-time unexposed to vaccine (adjusted rate ratio = 1.57\, 95% confidenc
 e interval: 1.02\, 2.21)\, corresponding to 0.74 excess GBS cases per mill
 ion pH1N1 vaccine doses (95% confidence interval: 0.04\, 1.56). This exces
 s risk was much smaller than that observed during the 1976 vaccine campaig
 n and was comparable to some previous seasonal influenza vaccine risk asse
 ssments. 
LOCATION:Large Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
END:VEVENT
END:VCALENDAR