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SUMMARY:From healing wounds to breaking bones – the many activities of i
 mmunoglobulin G - Prof Falk Nimmerjahn\, University of Erlangen-Nürnberg 
DTSTART:20130315T130000Z
DTEND:20130315T140000Z
UID:TALK42236@talks.cam.ac.uk
CONTACT:Dr Tennie Videler
DESCRIPTION: \nIgG antibodies are the primary mediators of protective humo
 ral immunity against pathogens and have been used therapeutically for over
  a century. They were first used as antitoxins for the treatment of infect
 ious diseases in the pre-antibiotic era. Today\, hyperimmune sera from hum
 an donors recovering from infection with specific viruses\, such as hepati
 tis B\, cytomegalovirus\, and varicella zoster\, are used to provide prote
 ctive immunity to susceptible populations. Moreover\, tumor specific antib
 odies have been successfully used in human cancer therapy. Besides these p
 rotective activities\, IgG autoantibodies are the principal mediators of a
 utoimmune diseases such as immune thrombocytopenia (ITP)\, autoimmune hemo
 lytic anemia (AHA)\, and systemic lupus erythematosus (SLE). The presentat
 ion will discuss which molecular and cellular factors influence IgG activi
 ty and how we can use this knowledge to enhance the therapeutic and block 
 the self-destructive activity of IgG molecules. Moreover\, a short outlook
  into novel humanized mouse models for understanding how human IgG molecul
 es function in vivo will be provided.
LOCATION:Sackler Lecture Theater on level 7 of the CIMR (Cambridge Institu
 te for Medical Research)
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