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SUMMARY:Proteins\, Crystals and mechanisms - Paul Elliott
DTSTART:20130307T131000Z
DTEND:20130307T140000Z
UID:TALK42271@talks.cam.ac.uk
CONTACT:Sven Friedemann
DESCRIPTION:Structural biology provides a fundamental molecular understand
 ing of biological processes. One of the most common ways to determine a pr
 otein structure is through its crystallisation and subsequent exposure to 
 X-rays. Within this talk I shall highlight how one goes from a protein in 
 solution to a crystal and finally to a three-dimensional structure. Along 
 this way I shall point out some of the most common pitfalls that we face\,
  almost seemingly on a daily basis.  Finally\, I will demonstrate with a s
 pecific example form our current research how structures provide a rationa
 l for enzyme mechanism and a more global implication in cellular signallin
 g. This provides potential pharmacological targets for treating human dise
 ases.
LOCATION:1 Newnham Terrace\, Darwin College
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