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SUMMARY:The Function of the Bacterial Cytoskeleton in the Virulence of Sal
 monella - Dr. C. M. Anjam Khan\, Institute for Cell and Molecular Bioscien
 ces\, The Medical School\, University of Newcastle
DTSTART:20130220T163000Z
DTEND:20130220T173000Z
UID:TALK42346@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:The view that bacteria do not possess a cytoskeleton has radic
 ally changed in recent years. Intracellular protein assemblies resembling 
 eukaryotic cytoskeletal elements have been identified in bacteria. These b
 acterial proteins play key roles in cellular morphology\, DNA segregation\
 , and cell division. However\, there are significant gaps in our knowledge
  on the function of the bacterial cytoskeleton in the virulence of pathoge
 ns. We have addressed this knowledge-gap and identified the existence of a
 n actin-like cytoskeleton in Salmonella. Furthermore\, the importance of t
 hese cytoskeletal elements to the ability of Salmonella to cause disease h
 as been explored. Using a broad range of independent experimental approach
 es\, we demonstrate the actin-like cytoskeleton impacts upon cellular morp
 hology\, motility\, type 3 secretion systems\, and the ability of Salmonel
 la to cause disease in vivo. The bacterial cytoskeleton represents an attr
 active target for novel anti-infectives.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
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