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SUMMARY:Hydra\, a model for deciphering the principles of stem cells and r
 egeneration - Brigitte Galliot\, Geneva\, Switzerland
DTSTART:20130206T130000Z
DTEND:20130206T140000Z
UID:TALK42704@talks.cam.ac.uk
CONTACT:25354
DESCRIPTION:Research performed on vertebrate and invertebrate model system
 s have demonstrated the potential of adult stem cells that represent a hop
 e for regenerative medicine. In parallel since 2006\, we know that differe
 ntiated cells can be manipulated as such as they reactivate their stem cel
 l potential. Beside the pressure of patients for regenerative medicine\, t
 here is a need to better understand the mechanisms that regulate cellular 
 as well as tissue plasticity. Hydra is a small freshwater cnidarian polyp 
 that exhibits a highly dynamic maintenance of its body shape and fitness\,
  a strong regenerative potential upon injury\, and a low senescence. As su
 ch it provides a unique model system to investigate the relationships betw
 een tissue plasticity and regenerative potential. Hydra properties rely on
  three distinct stem cell populations that cannot replace each other\, ect
 odermal and endodermal epithelial stem cells\, both unipotent\, and inters
 titial stem cells\, multipotent. Surprisingly the suppression of the multi
 potent interstitial cells is compatible not only with survival of the anim
 al but also with the reactivation of their adult developmental programs\, 
 i.e. regeneration and asexual reproduction \,i.e. budding. I will present 
 experimental strategies that investigate the specific properties of these 
 three stem cell populations\, their cycling activity\, their resistance to
  cell death\, their response to injury and the molecular pathways linked t
 o these behaviors.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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