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SUMMARY:Evolution of gastrulation in flies - Steffen Lemke\, Heidelberg\, 
 Germany
DTSTART:20130220T130000Z
DTEND:20130220T140000Z
UID:TALK42706@talks.cam.ac.uk
CONTACT:Jack Green
DESCRIPTION:The morphology of an organism is shaped during its development
 \, and ultimately\nadult form rests on sequential changes in the shape of 
 cells and tissues.\nMorphological differences between two species are gene
 rated by diverging\ndevelopmental trajectories. To assess the molecular pr
 inciples contributing to\nthe evolution of form\, we study gastrulation as
  a genetically tractable model\nof (transient) morphogenesis. Specifically
 \, we compare gastrulation in\ndistantly related flies (Diptera) at the ce
 llular and genetic level with the\naim to identify common genetic and cell
  biological principles of morphological\nevolution. As fly gastrulation fo
 llows a similar set of morphogenetic\ntransformations\, it can be readily 
 compared\; yet it has diverged sufficiently\nenough between flies to be ab
 le to explore morphogenetic differences. Over the\nlast years\, we and oth
 ers have established lab cultures and molecular genetic\ntools for basic g
 ain- and loss-of-function approaches in multiple species at\nkey positions
  in the Dipteran phylogeny. I will discuss experimental approaches\nwe are
  taking to study the evolution of Dipteran gastrulation.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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