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SUMMARY:Mobile silencing RNAs - Attila Molnar\, Gene Silencing
DTSTART:20130222T130000Z
DTEND:20130222T133000Z
UID:TALK42765@talks.cam.ac.uk
CONTACT:24938
DESCRIPTION:RNA silencing is a gene regulation mechanism that controls dev
 elopment\, stress responses and molecular parasites such as viruses\, tran
 sgenes and transposons. In flowering plants\, one of the most fascinating 
 aspects of RNA silencing is its non-cell autonomous nature. RNA silencing 
 involves a signal that can spread from the site of initiation to neighbour
 ing cells via plasmodesmata and over long distances through the phloem. Th
 e signal has nucleotide sequence specificity\, and recent publications fro
 m the Voinnet and Baulcombe lab have demonstrated that small non-coding RN
 As [sRNAs\, 21-24 nucleotide (nt)] are key components of the mobile RNA si
 lencing signal. sRNAs are generated by diverse and sometimes interacting b
 iochemical pathways and the different sized sRNAs have distinct roles in R
 NA silencing. The 21nt sRNAs primarily mediate post-transcriptional silenc
 ing (PTGS) that involves mRNA cleavage/destabilization or translational in
 hibition in the cytoplasm. The 24 nt sRNAs are associated with nuclear eve
 nts including RNA-dependent DNA methylation (RdDM) and histone modificatio
 ns that can lead to transcriptional gene silencing (TGS). I will discuss t
 he consequences of mobile sRNAs on target gene expression.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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