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SUMMARY:sRNAs: Initiators of transgenerational epigenetic inheritance in A
 rabidopsis thaliana - Donna Bond\, Gene Silencing
DTSTART:20130315T130000Z
DTEND:20130315T133000Z
UID:TALK42768@talks.cam.ac.uk
CONTACT:24938
DESCRIPTION:Genetic mechanisms alone are unable to explain how some traits
  are propagated from one generation to the next. Epigenetic modifications\
 , such as DNA methylation and post-translational modification(s) of histon
 e tails are widely accepted as playing a critical role in regulating gene 
 expression. In general\, these modifications are cleared and re-establishe
 d each generation. However\, at some genomic loci this erasure is incomple
 te and the epigenetic state of the parent is transmitted to the progeny\; 
 a phenomenon referred to as transgenerational epigenetic inheritance. In f
 lowering plants\, small non-coding RNAs (21-24 nucleotide in length) are r
 equired for initiation of heritable epigenetic modifications such as DNA m
 ethylation. I am interested in understanding how sRNA populations change i
 n response to different environmental conditions and whether these changes
  can alter the epigenetic state of target loci and lead to heritable pheno
 typic variation. In addition\, I am exploiting additional sRNA-mediated me
 chanisms (such as the anti-viral defence mechanism) to aid our understandi
 ng of how and when transgenerational epigenetic inheritance can be establi
 shed and maintained in plants. 
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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