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SUMMARY:The day within: circadian clock genes\, cells and circuits - Dr Mi
 chael Hastings\, FRS  [MRC LMB\, Cambridge]
DTSTART:20130130T190000Z
DTEND:20130130T203000Z
UID:TALK42826@talks.cam.ac.uk
CONTACT:Thomas Irving
DESCRIPTION:_Circadian rhythms are those daily cycles of behavior\, physio
 logy and metabolism that persist with a period of approximately 24 hours w
 hen individuals are held in a time-free environment.  Their persistence  b
 etrays their maintenance by an internal clock or circadian pacemaker\,  in
  mammals the principal being the suprachiasmatic nucleus of the  hypothala
 mus.   The cycle of sleep and wakefulness is the most obvious  circadian r
 hythm and sets the very tempo of our lives.  Disruption of  the SCN by dis
 ease\, trauma\, and pharmacological or genetic manipulation  perturbs our 
 circadian life.  This presentation will review current  knowledge of how t
 he SCN operates as an autonomous neural clock\,  considering in particular
  the pacemaking activity of transcriptional  feedback loops based upon cir
 cadian clock genes Period and Cryptochrome.  It will also consider how SCN
  neurons operate together in  a coherent circuit to deliver to other brain
  regions a synchronised  circadian signal.  Finally it wil consider the ro
 le of clocks in health._
LOCATION:Large Lecture Theater\, Department of Plant Sciences\, Downing Si
 te
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