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SUMMARY:Predicting and exploiting mechanism within protein interaction net
 works  - Professor Rob Russell\, University of Heidelberg
DTSTART:20130122T160000Z
DTEND:20130122T170000Z
UID:TALK43120@talks.cam.ac.uk
CONTACT:Christine McLoughlin
DESCRIPTION:Mechanistic details of how protein interactions are mediated a
 re important for understanding and perturbing biological processes.  Howev
 er\, such details (most often in the form of experimental 3D structures) a
 re largely absent for the majority of interactions determined via interact
 ion discovery methods. To address this gap we have developed several predi
 ctive tools during the past decade that can either produce fast models of 
 interactions or predict the means by which two proteins interact via short
  linear motifs.  We are applying these tools to allow the discovery of new
  interaction modules and to help to understand new datasets produced by ne
 xt generation sequencing project or proteomics methods directed (for examp
 le) towards the discovery of post-translational modifications.  In this ta
 lk I will summarise our methods and discuss our key recent applications of
  these methods.\n
LOCATION:Department of Biochemistry\, Hopkins Building\, Seminar Room 1
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