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SUMMARY:Exploiting cancer stem cells for the identification of mediators i
 nvolved in brain tumorigenesis - Dr Rossella Galli\, Stem Cell Biology Uni
 t\, San Raffaele Scientific Institute\, Milan\, Italy
DTSTART:20130228T143000Z
DTEND:20130228T153000Z
UID:TALK43124@talks.cam.ac.uk
CONTACT:Dr Ireena Dutta
DESCRIPTION:Brain tumors are characterized by rapid growth characteristics
  and extreme invasive behavior\, thus being inherently resistant to conven
 tional therapy. Therefore\, improvement of treatment options for patients 
 with BTs is imperative. BTs comprise subpopulations of cancer stem cells (
 CSCs)\, which are capable to initiate and sustain tumor development. These
  CSCs phenocopy the tumors of origin\, and\, as such\, are envisioned as a
  novel and valuable preclinical model to develop new therapeutic approache
 s for BTs. In particular\, gene expression profiles of BT CSCs\, which are
  characterized by cell line-specific molecular and phenotypic traits\, can
  be exploited in order to identify CSC-restricted molecular mediators\, wh
 ich hold significant advantages in terms of cell-targeting specificity and
  therapeutic exploitability.
LOCATION:Sackler Lecture Theatre\, CIMR\,  Level 7
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