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SUMMARY:Integration of functional genomics and pathway information to eluc
 idate deregulation of signal transduction and drugs' mode of action - Dr. 
 Julio Saez-Rodriguez\, EMBL-European Bioinformatics Institute
DTSTART:20130123T140000Z
DTEND:20130123T150000Z
UID:TALK43145@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:In this review we will describe recent efforts to integrate si
 gnal transduction pathways with various sorts of genomics data\, with the 
 aim to find key regulators of gene expression and mechanisms of signal tra
 nsduction. We will focus on applications related to human disease\, and ex
 plore how these methods can be used to study drug's mode of action. Genomi
 c (in particular gene expression) data has been proposed as tool for drug 
 discovery.  Here\, we will explore how approaches that include prior knowl
 edge on the underlying biochemical processes provide deeper mechanistic in
 sight and enhance the power of genomic data to develop novel therapies for
  diseases such as cancer.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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