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SUMMARY:Euler's elasticas and their applications to DNA\, nucleosomes and 
 chromatin fibers - Prof Helmut Schiessel (Leiden)
DTSTART:20130208T140000Z
DTEND:20130208T150000Z
UID:TALK43401@talks.cam.ac.uk
CONTACT:Shery Huang
DESCRIPTION:In the year 1744 Leonard Euler gave the first modern formulati
 on for the energetics underlying the bending of elasticas\, thin elastic s
 trips. This theory is of great importance for the understanding of the beh
 avior of DNA inside the chromatin complex\, the DNA-protein complex that f
 ills the nuclei of plant and animal cells. After introducing the history o
 f the Euler elasticas\, I shall present three applications and extensions 
 of Euler's theory to the various levels of the hierarchical chromatin comp
 lex:\n(1) DNA: multiple plectoneme formation for DNA under twist\n(2) Nucl
 eosomes: kinetic protection against tension\n(3) Chromatin fibers: fiber g
 eometry as a packing problem\nThe presented theoretical models allow a qua
 ntitative understanding of puzzling experimental observations and suggest 
 biological implications.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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