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SUMMARY:Genome sequencing of transmissible cancers in dogs and Tasmanian d
 evils - Elizabeth Murchison (Sanger) 
DTSTART:20130227T140000Z
DTEND:20130227T150000Z
UID:TALK43813@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:Each individual cancer is a clonal cell lineage that emerges t
 hrough an\nevolutionary process when a single cell of the body acquires so
 matic\nmutations that drive proliferation and survival. As it develops\, c
 ancer\ncan spread through the body to invade distant tissues. However\, it
  does\nnot normally spread or survive outside of the body. Clonally\ntrans
 missible cancers are clonal cell lineages that survive beyond the\ndeaths 
 of their hosts by acquiring adaptations for transmission between\nhosts. R
 are examples of cancer transmission between humans have been\nreported due
  to transfer of cancer cells in utero\, by surgical injury\,\nby experimen
 tal inoculation and by inadvertent transplantation of cancer\ncells with d
 onated organs. However\, there are only two known naturally\noccurring clo
 nally transmissible cancers that have spread between\nmultiple hosts and t
 hese are the transmissible venereal tumour of dogs\nand the facial tumour 
 of Tasmanian devils. These two cancers are\nspecialised parasitic clonal c
 ell lineages that spread between\nindividuals through physical contact and
  have survived long after the\ndeaths of the animals from which they origi
 nally emerged.\n
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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