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SUMMARY:Immune profiling the human NK cell repertoire using mass cytometry
  (CyTOF) - Dr Amir Horowitz\, Stanford University
DTSTART:20130409T113000Z
DTEND:20130409T123000Z
UID:TALK44240@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:The Parham laboratory investigates the biology\, genetics and 
 evolution of MHC class I molecules and Natural Killer (NK) cell receptors 
 (NKRs). \n\nTo provide a framework for understanding how perturbations in 
 expression of NKRs influence disease pathogenesis\, we defined the phenoty
 pic heterogeneity of NK cells in 22 healthy individuals\, including 5 sets
  of monozygotic twins.\n\nUsing mass cytometry\, surface expression of 38 
 markers specific for NKRs and lineage markers to identify B cells\, T cell
 s and myeloid cells were examined. KIR and HLA class I genotypes were dete
 rmined by Luminex\, and KIR gene content was further assessed using pyrose
 quencing\, in order to better appreciate how these cells are educated and 
 subsequently regulated.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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