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SUMMARY:Chemotaxome – A new member with complex biological entities in s
 ystems biology. - Kohidai\, Laszlo MD\, PhD\, Med.Habil. Cell Biology\, As
 soc. Professor Chemotaxis Research Group – SRI Core Facility Department 
 of Genetics\, Cell- &amp\; Immunobiology\, Semmelweis University\, Budapes
 t\, Hungary
DTSTART:20130412T130000Z
DTEND:20130412T140000Z
UID:TALK44324@talks.cam.ac.uk
CONTACT:Alessio Zaccone
DESCRIPTION:Sequence of cell-physiological responses arranged via axis of 
 cell adhesion –\nchemotaxis – phagocytosis\, embodies one of the most 
 fundamental elements of\nfunctional biology.  Migratory responsiveness of 
 cells is in the focus of the\nmatrix describing the interaction of the thr
 ee components and provides\ncharacteristic links between the members of th
 e system. Integrated cellular\,\nbiomaterial and functional complexity of 
 the system justify the description of\n’Chemotaxome’ as a new member o
 f ’Class Omes’\, which recommendation is\nsupported by different level
 s of systems biology.\nThe most significant components of the network are 
 summarized in the next\npoints: (i) potential for migartion is a basic\, h
 owever\, individual entity of\nprokaryotic (bacteria) and eukaryotic cells
  (i.e. ciliates\, amoebas\, sperm\,\nWBCs etc.)  belonging to different ta
 xa (Taxonome)\; (ii) itself\nchemotaxis/chemokinesis represent a character
 istic type of cell biological\nresponses and covers a wide scale of respon
 ses in healthy tissues/individuals\n(i.e. fertilization\, differentiation 
 of tissues\, angiogenesis) as well as in\npathological cases (i.e. inflamm
 ation\,  metastasis formation) with a special\nrespect on the clinical app
 roaches of the field (Functiome)\; (iii) classes of\nsignalling molecules 
 (i.e. chemokines\, formyl peptides as well as\nnon-professional chemoattra
 ctants) are required for chemotaxis\, while\nchemotaxis receptors (i.e. FP
 R\, CCR\, CXCR) and their intracellular signalling\npathways have unique s
 ensitivity towards to the triggering chemoattractant\n(Ligandome\, Regulom
 e\, Interactome\, Proteome-Glycome-Lipidome)\; genetic\ndetermination of a
 ll the interacting components mentioned above are coded in\nthe DNA of  th
 e cell (i.e. IL-8 - 4q13-q21\; IL-8R - 2q35-2q36.1) (Genome)\;\nwhile comp
 lex relations of molecular genetic  backgrounds and phylogenetic\napproach
 es (i.e. amino acids of prebiotic soup\;  chemotactic selection) are\nbelo
 nging to the molecular aspects of evolution (Phylogenome).\nGlory of the f
 ield is gained from a list of famous researchers of post and\npresent (Lee
 uwenhoek\, Engelmann\, Pfeffer\, Metchnikoff and Adler) who contribute\nwi
 th novel theoretical (i.e. bacterial network of Che peptides) and practica
 l\nparts (i.e. new assays\; molecular genetic evaluation) of the field. On
  the\nbasis of the above described system a complete and extensive\, Chemo
 taxome\nspecific network of informatics\n(sequence-structure-expression-pa
 thway-regulation) could be also designed with\na high significance in resp
 ect of citation of chemotaxis and its scientific\nsynonyms in contrast oth
 er\, non chemical stimuli induced migratory responses.\n
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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