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SUMMARY:How modifications to proteins lead to Parkinson's Disease - Alex v
 an der Wateren
DTSTART:20130425T121000Z
DTEND:20130425T130000Z
UID:TALK44542@talks.cam.ac.uk
CONTACT:Sven Friedemann
DESCRIPTION:Parkinson’s disease is a neurodegenerative disease character
 ized by inclusions of a small intrinsically disordered protein (14 kDa)\, 
 α‐synuclein (AS) in Lewy Bodies. Modifications to AS\, such as point mu
 tations (A30P\, A53T\, E46K)\, phosphorylation of Tyrosine 125 and Serine 
 129\, N-terminal acetylation as well as C‐terminal truncations might aff
 ect functioning of the protein as well as its aggregation behaviour into a
 myloid fibrils. However\, detailed mechanistic understanding of the molecu
 lar events that lead to the conversion of soluble protein into insoluble a
 ggregates is currently lacking for AS.\nI will give a short introduction t
 o neurodegenerative diseases in general and explain how my research aims t
 o elucidate the mechanisms that operate in Parkinson's Disease.
LOCATION:1 Newnham Terrace\, Darwin College
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