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SUMMARY:Rho GTPases in pulmonary vascular remodelling - Dr Beata Wojciak-S
 tothard\, Imperial College London
DTSTART:20130418T120000Z
DTEND:20130418T130000Z
UID:TALK44553@talks.cam.ac.uk
CONTACT:Eve Dillon
DESCRIPTION:Rho GTPases\, best known for their regulatory role in actin dy
 namics\, stimulate a variety of processes important in control of vascular
  function\, including morphogenesis\, migration\, cell proliferation and a
 dhesion\, cell survival\, gene expression\, vesicle transport and micropar
 ticle formation. Recent data implicate Rho GTPase RhoB in the regulation o
 f pulmonary vascular remodelling in pulmonary hypertension. This lecture w
 ill discuss signalling mechanisms involved in Rho-induced pulmonary vascul
 ar dysfunction and identify potential targets for pharmacological interven
 tion. 
LOCATION:Seminar room 3\, Clinical School\, Addenbrookes
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