BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Molecular mechanisms of synapse degeneration in prion and Alzheime
 r's disease - Dr Clive Bate\, Pathology &amp\; Infectious Diseases\, The R
 oyal Veterinary College
DTSTART:20130515T151500Z
DTEND:20130515T161500Z
UID:TALK44565@talks.cam.ac.uk
CONTACT:Suzy Blows
DESCRIPTION:Synapse degeneration is the key event leading to memory failur
 e in Alzheimer's and prion diseases. Prions and amyloid-beta42 (thought to
  be the major neurotoxin in Alzheimer's disease) trigger synapse damage in
  cultured neurons. In this talk I will discuss the molecular mechanisms of
  synapse damage in response amyloid-beta42 and prions including experiment
 al data implicating the role of specific receptors\, lipid rafts and signa
 lling cascades. I will then discuss possible intervention strategies based
  on the manipulation of these molecular pathways.
LOCATION:Lecture Theatre 1\, Department of Veterinary Medicine
END:VEVENT
END:VCALENDAR