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SUMMARY:The impact of cohesin on the regulation of gene expression and  th
 e organization of chromatin. - Matthias Merkenschlager     Lymphocyte Deve
 lopment Group\, MRC Clinical Sciences Centre\, Imperial College London\, D
 u Cane Road\, London W12 0NN\, UK 
DTSTART:20130423T160000Z
DTEND:20130423T164500Z
UID:TALK44570@talks.cam.ac.uk
CONTACT:Viji M. Draviam
DESCRIPTION:Cohesin-mediated sister chromatid cohesion is essential for ch
 romosome segregation and post-replicative DNA repair. Growing evidence fro
 m human genetics and model organisms links cohesin to the formation of lon
 g-range chromosomal interactions and to the regulation of gene expression 
 in association with CTCF\, mediator\, or tissue-specific transcription fac
 tors. We have taken genetic approaches to determine the impact of cohesin 
 on developmentally regulated gene expression and the organization of chrom
 atin in non-dividing mammalian cells. Since gene dosage reductions in the 
 cohesin loading factor Nipbl are the leading cause of Cornelia de Lange sy
 ndrome\, we have also investigated the transcriptional and post-transcript
 ional regulation of Nipbl expression.
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