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SUMMARY:Direct Nuclear Pore Complex Regulation of T-cell Induced Inflammat
 ion - Professor Chris Rudd\, Dept of Pathology\, University of Cambridge
DTSTART:20130424T113000Z
DTEND:20130424T123000Z
UID:TALK44581@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:We are interested in the receptor-mediated signals that regula
 te the activation and function of T-cells.  The antigen-receptor complex (
 TCR) activates T-cells via the activation of src kinases and ZAP-70 leadin
 g to the phosphorylation of the adaptor protein linker for the activation 
 of T-cells (LAT).  Despite its importance\, it has been unclear whether LA
 T is solely coupled to the TCR\, or whether it can undergo changes in comp
 osition in the regulation of T-cell function.\n \nI will present data show
 ing that co-receptors can alter the composition of the LAT signalosome by 
 displacing associated GADs-SLP-76 complexes. These observations show for t
 he first time that co-receptors can intersect directly with TCR signaling 
 by altering the composition of the LAT signalosome in T-cells.  \n\nIn the
  second part of my talk\, I will discuss recent work showing that the adap
 tors can directly bind and modulate the nuclear pore complex (NPC) in T-ce
 lls for the transport of transcription factors such as NFAT\, needed for t
 he production of pro-inflammatory cytokines.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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