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SUMMARY:Foxp3\, TSLP\, and the regulation of immunity and inflammation - D
 r Steve Ziegler\, Benaroya Research Institute\, Seattle
DTSTART:20130508T113000Z
DTEND:20130508T123000Z
UID:TALK44584@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:The Ziegler lab is interested in factors that are involved in 
 regulating immune responses in beneficial and pathogenic ways.  We have id
 entified the transcriptional regulator Foxp3 as a critical factor in the d
 evelopment and function of regulatory T cells\, and have begun to define t
 he pathways that control peripheral regulatory T cell generation.  In addi
 tion\, we are examining the role of medulary thymic epithelial cells in th
 e development of regulatory T cells in the thymus.\n\nIn a separate set of
  studies we have found that the epithelial-derived cytokine TSLP (thymic s
 tromal lymphopoietin) is an important initiator of atopic disease.  Using 
 both human and mouse systems we have identified the cells that respond to 
 TSLP during allergic inflammatory responses\, and have begun to investigat
 e the pathways that are involved.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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