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SUMMARY:Macrophage heterogeneity and renewal during inflammation - Profess
 or Philip Taylor\, University of Cardiff
DTSTART:20130612T113000Z
DTEND:20130612T123000Z
UID:TALK44588@talks.cam.ac.uk
CONTACT:Sue Griffin
DESCRIPTION:We have been studying macrophage heterogeneity during inflamma
 tion and these studies have revealed that even in vascular tissues\, tissu
 e resident macrophages can be maintained as an independent self-renewing p
 opulation of cells. \n\nThese cells are seeded into the tissue during deve
 lopment\, expanded during the neonatal period and remarkably we found they
  were capable of remaining independent of bone marrow input during the rec
 overy from inflammation. Proliferative renewal is not restricted to tissue
  resident macrophages as inflammatory bone marrow derived macrophages also
  proliferate during the resolution of inflammation. The autonomy of distin
 ct macrophage lineages\, within specific tissues\, underscores the extensi
 ve heterogeneity of tissue resident macrophages\, which is a necessary con
 sequence of tissue and microanatomical niche specific functions. These dis
 crete phenotypes must necessarily be dictated by specific transcriptional 
 controls. \n\nThe identification of cell specific transcription factors an
 d the consequences of their disruption will be discussed.\n
LOCATION:Lecture Theatre\, Department of Pathology\, Tennis Court Road
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