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SUMMARY:Biological insights from cryo-EM studies of complex macromolecular
  assemblies in transcription initiation and microtubule dynamics - Eva Nog
 ales\, HHMI University of California Berkely
DTSTART:20130724T151500Z
DTEND:20130724T170000Z
UID:TALK44716@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:We are interested in the mechanistic understanding of essentia
 l eukaryotic molecular processes. Our research centers on cell division ro
 les of the cytoskeleton\, and on the making and breaking of macromolecules
  by molecular machines governing the flow of genetic information. We are v
 isualizing these complex assemblies as whole units of molecular function u
 sing cryo-electron microscopy to characterize their architecture\, functio
 nal states and regulatory interactions. I will talk about our studies on t
 he assembly of the human transcription pre-initiation complex\, and about 
 recent results concerning the effect of nucleotide and drug binding on the
  structure of microtubules.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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