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SUMMARY:Modularity and maturation of brain networks in childhood-onset sch
 izophrenia - Aaron Alexander-Bloch\, Department of Psychiatry\, University
  of Cambridge
DTSTART:20130528T100000Z
DTEND:20130528T110000Z
UID:TALK44752@talks.cam.ac.uk
CONTACT:Mikail Rubinov
DESCRIPTION:Schizophrenia is increasingly understood to target the develop
 ment of brain connectivity. A property of particular interest is the modul
 arity or community structure of brain networks\, which can be derived from
  structural or functional MRI. Modules or sub-communities of brain regions
  possess unusually high within-community connectivity and low between-comm
 unity connectivity. Theoretically\, the modularity of networks has been li
 nked to their successful evolution and development\, suggesting altered mo
 dularity as a possible mechanism for neurodevelopmental disease. Childhood
 -onset schizophrenia\, which begins before age 13 and is approximately 100
  times less frequent than adult-onset schizophrenia\, represents a unique 
 opportunity to test this hypothesis in a developing population. Our resear
 ch suggests that fMRI brain networks of people with COS do indeed have alt
 ered modular structure\, with relatively decreased short-distance\, intra-
 modular functional connectivity. This hypothesis is also supported by stru
 ctural imaging studies. Longitudinal brain imaging of typically developing
  children demonstrates modules of regions that show synchronized maturatio
 n of cortical thickness\, and altered maturational trajectories in COS app
 ear within specific developmental modules.\n
LOCATION:MRC CBU lecture theatre\, 15 Chaucer Road
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