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SUMMARY:MR imaging and biomechanical analysis: the assessment of carotid a
 therosclerotic plaque vulnerability - Dr Zhongzhao Teng\,  University Depa
 rtment of Radiology\, University of Cambridge
DTSTART:20130531T130000Z
DTEND:20130531T140000Z
UID:TALK45005@talks.cam.ac.uk
CONTACT:Ms Helen Gardner
DESCRIPTION:Stroke is the third leading cause of death in the developed co
 untries and the most common cause of long term disability.  Carotid artery
  atherosclerotic disease is the predominant precipitant of ischaemic event
 s. Conventionally\, angiography is used for the clinical assessment. Howev
 er\, angiography identifies only those lesions that encroach significantly
  into the lumen\, and there is a poor correlation between the angiographic
  appearance of plaques and subsequent risk of plaque rupture. Efforts from
  the past 30 years indicate that atherosclerotic plaque vulnerability has 
 a close relationship with certain morphological features\, including fibro
 us cap thickness\, size of lipid-rich necrotic core\, presence of haemorrh
 age and luminal contours. Moreover\, recent results indicate that critical
  mechanical conditions are additional driving factors in plaque rupture\, 
 when plaque loading exceeds material strength.\n\nAccordingly this talk wi
 ll focus on: (1) characterisation of morphology and compositional features
  in atherosclerotic plaque and its relationship with subsequent clinical e
 vents using in-vivo magnetic resonance (MR) imaging\; (2) medical image-ba
 sed mechanical analysis to seek new non-invasive bio-markers for plaque vu
 lnerability assessment\; and (3) the pathological impact of critical mecha
 nical conditions within the plaque structure.
LOCATION:Oatley Seminar Room\, Department of Engineering
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