BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Intrinsic biophysical diversity and connectivity of neuronal circu
 its - Troy Margrie\, NIMR
DTSTART:20130611T160000Z
DTEND:20130611T170000Z
UID:TALK45509@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:A neuron’s intrinsic biophysical profile together with its a
 natomical and functional connectivity defines its function. Although diffe
 rent classes of neurons are known to express different constellations of m
 embrane channels\, very few studies have quantified such biophysical diver
 sity across the population of a single class. I will present recent data o
 btained from principal cells in the olfactory bulb investigating the relat
 ionship between the biophysical profile of an individual neuron and its fu
 nction. In the second part of the talk I will describe our recently develo
 ped tool that enables us to assess the biophysical and sensory properties 
 of an individual neuron in vivo\, then to trace the upstream connectivity 
 profile of that cell. We have implemented a fully automated serial two-pho
 ton microscope that facilitates high-throughput analysis of large-scale co
 nnectivity datasets. This will allow us to establish a three-dimensional f
 unctional connectivity atlas of single cells and information pathways in t
 he brain.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
END:VEVENT
END:VCALENDAR