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SUMMARY:Wakefulness\, locomotion\, and navigation: a look from visual cort
 ex - Professor Matteo Carandini\, GlaxoSmithKline - Fight for Sight Profes
 sor of Visual Neuroscience\, UCL Institute of Ophthalmology
DTSTART:20131010T160000Z
DTEND:20131010T170000Z
UID:TALK45811@talks.cam.ac.uk
CONTACT:Emma
DESCRIPTION:Most of what we know on primary visual cortex (V1) comes from\
 nexperiments performed under anesthesia. Yet visual cortex is typically\nu
 sed by awake animals while they actively navigate an environment. I\nwill 
 describe three studies recently performed in my laboratory to\ninvestigate
  how visual processing in mouse V1 is affected by\nwakefulness\, locomotio
 n\, and navigation.  The first study\, by Bilal\nHaider\, indicates that w
 akefulness dramatically enhances synaptic\ninhibition\, abolishing the bal
 ance of excitation and inhibition\ntypically seen in V1 under anesthesia. 
 The second study\, by Asli Ayaz\,\nindicates that locomotion profoundly al
 ters spatial integration\,\ngreatly reducing the surround suppression that
  is common in V1 neurons\nof stationary animals. The third study\, by Aman
  Saleem\, reveals that\nV1 signals are modulated by virtual navigation\, i
 n a way that is\nideally suited to code for the visual stimuli created by 
 locomotion in\nthe environment. These results indicate that visual process
 ing in\nmouse V1 is profoundly affected by wakefulness\, locomotion\, and\
 nnavigation\, and reinforce the need for studying the cerebral cortex\ndur
 ing natural behavior.\n
LOCATION:MRC LMB: Klug Seminar Room 2A180
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