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SUMMARY:Active stresses and mechanics of intra/extracellular networks - Ma
 cKintosh\, F (Vrije Universiteit Amsterdam)
DTSTART:20130627T080000Z
DTEND:20130627T084500Z
UID:TALK45951@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Much like the bones in our bodies\, the cytoskeleton consistin
 g of filamentous proteins largely determines the mechanical response and s
 tability of cells. Similarly\, extracellular networks contribute to tissue
  mechanics. Unlike passive materials\, however\, living cells are kept far
  out of equilibrium by metabolic processes and energy-consuming molecular 
 motors that generate forces to drive the machinery behind various cellular
  processes. We describe recent advances both in theoretical modeling of su
 ch active gels\, as well as experiments on reconstituted in vitro acto-myo
 sin networks and living cells. We show how such internal force generation 
 by motors can lead to dramatic mechanical effects\, including strong mecha
 nical stiffening. Furthermore\, stochastic motor activity can lead to non-
 equilibrium diffusive-like motion in cells.\n
LOCATION:Seminar Room 1\, Newton Institute
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