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SUMMARY:A poroelastic model for mechanochemical waves and pattern formatio
 n in Physarum polycephalum - Baer\, M (Physikalisch-Technische Bundesansta
 lt (PTB))
DTSTART:20130628T104500Z
DTEND:20130628T113000Z
UID:TALK45975@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Many processes in living cells are controlled by biochemical s
 ubstances regulating active stresses. The cytoplasm is an active material 
 with both viscoelastic and liquid properties. First\, we incorporate the a
 ctive stress into a two-phase model of the cytoplasm which accounts for th
 e spatiotemporal dynamics of the cytoskeleton and the cytosol. The cytoske
 leton is described as a solid matrix that together with the cytosol as int
 erstitial fluid constitutes a poroelastic material. We find different form
 s of mechanochemical waves including traveling\, standing and rotating wav
 es by employing linear stability analysis and numerical simulations in one
  and two spatial dimensions. \n\nIn a second step\, we expand the chemo-me
 chanical model in order to model the manifold contraction patterns observe
 d experimentally in protoplasmic droplets of Physarum polycephalum. To ach
 ieve this\, we combine a biophysically realistic model of a calcium oscill
 ator with the poroelastic model derived in the first part of the talk and 
 assume that the active tension is regulated by calcium. With the help of t
 wo-dimensional simulations the model is shown to reproduce the contraction
  patterns observed in in protoplasmic droplets as well as a number of othe
 r traveling and standing wave patterns. \n\nCo-authors: Markus Radszuweit 
 (PTB Berlin)\, Sergio Alonso (PTB Berlin)\, Harald Engel (TU Berlin )\n
LOCATION:Seminar Room 1\, Newton Institute
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