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SUMMARY:Modeling dorsal closure during embryonic development of the fruit 
 fly - Feng\, J (University of British Columbia)
DTSTART:20130628T084500Z
DTEND:20130628T093000Z
UID:TALK45977@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:This talk concerns "dorsal closure"\, a dynamic and complex pr
 ocess during the embryogenesis of Drosophila. Experiments have documented 
 distinct phases of dorsal closure\, each with rich and sometimes contradic
 tory observations. We build a mathematical model to rationalize the result
 s and test various hypotheses put forth by experimenters. The cells are co
 upled mechanically through the position of the nodes and the elastic force
 s on the edges. Besides\, each cell has radial spokes on which myosin moto
 rs can attach and exert contractile forces on the nodes\, the myosin dynam
 ics itself being controlled by a signaling molecule. This simple model suc
 cessfully reproduces the cell and tissue pulsation in the early phase of d
 orsal closure\, as well as the consistent contraction in the slow phase th
 rough a cellular ratcheting mechanism.\n\nCo-authors: Qiming Wang (Univ of
  British Columbia)\, Len Pismen (Technion)\n\n
LOCATION:Seminar Room 1\, Newton Institute
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