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SUMMARY:Ultra high accuracy (UAIM) superresolution microscopy of biologica
 l samples: How ugly images give better results than pretty ones - Professo
 r Raimund J. Ober\, Department of Electrical Engineering\, Department of B
 iomedical Engineering\, University of Texas at Dallas
DTSTART:20130705T130000Z
DTEND:20130705T141500Z
UID:TALK45981@talks.cam.ac.uk
CONTACT:Dr Jason Z JIANG
DESCRIPTION:Recent developments in microscopy have attracted a significant
  amount of interest in the biological community due to the promise that th
 ese new techniques can help to exploit\nthe molecular biology advances for
  the study of cellular processes.\n \nOne of these developments is single 
 molecule microscopy\, a technique by which individual single molecules can
  be imaged rather than the clusters of molecules of\nprior approaches. Sup
 erresolution microscopy exploits single molecule imaging and produces imag
 es with a resolution well beyond the classical resolution limits.\nA criti
 cal aspects of these techniques is the accurate localization of single mol
 ecules.\n \nHere we will review our results of the use of the Fisher infor
 mation to characterize the accuracy with which location parameters can be 
 extracted\nin single molecule microscopy. We will present recent results o
 n the modeling of electron multiplication CCD cameras. These techniques in
 spired new\, unconventional\, imaging\napproaches. Especially for extreme 
 low light imaging scenarios\, we show that these new modalities can lead t
 o superresolution images with unprecedented accuracies\nthat are close to 
 the theoretically best possible ones [1].\n\n[1] Chao\, J.\, Ram\, S.\, Wa
 rd\, E. S.\, Ober\, R. J. Ultrahigh accuracy imaging modality for super-lo
 calization microscopy. Nature Methods\, 10(4): 335-338\, 2013.
LOCATION:Cambridge University Engineering Department\, LR3A
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