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SUMMARY:Long-distance organelle transport in the neuron: mechanisms of mot
 or engagement and motor coordination - Erika Holzbaur\, University of Penn
 yslvania
DTSTART:20130905T151500Z
DTEND:20130905T170000Z
UID:TALK46161@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:The long distance transport of organelles along the axon is dr
 iven by the microtubule motors kinesin and cytoplasmic dynein.  This trans
 port is required to maintain the extended axons of neurons\; mutations in 
 either the motors or their activators and adaptors are sufficient to cause
  neurodegeneration.  We are focusing on the mechanisms regulating molecula
 r motor function during transport along the axon.  Active coordination of 
 opposing motors is essential\, as many vesicular cargos undergoing transpo
 rt along microtubules in the axon have both plus end-directed kinesins and
  minus-end directed dynein motors bound simultaneously.  We are investigat
 ing the role of scaffolding proteins including JIP1 and Huntingtin in coor
 dinating the activities of kinesin and dynein motors\, allowing for the pr
 ocessive and efficient long-range motility of diverse cargos including APP
 -positive vesicles and autophagosomes.  During retrograde transport\, effi
 cient initiation of vesicular transport requires the dynein activator dyna
 ctin as well as microtubule plus end-binding proteins including EB1.  Toge
 ther\, data from both live cell imaging and in vitro reconstitution experi
 ments with single molecule resolution can be used to build detailed models
  providing mechanistic insight into the regulation of motor coordination a
 nd motor engagement during axonal transport in neurons.
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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