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SUMMARY:Can structural studies of intact viruses really be useful in the s
 earch for better vaccines and antivirals? - David Stuart\, University of O
 xford
DTSTART:20131010T151500Z
DTEND:20131010T170000Z
UID:TALK46162@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:I will focus on picornaviruses\, small well-studied viruses re
 sponsible for a range of human and animal dieases (from polio to the commo
 n cold)\, against which we have a smattering of useful vaccines and very l
 ittle in the way of small molecule drugs. I will try to convince you that 
 the increasing facility of structure analysis of such viruses makes it wor
 th attempting to make better vaccines and new anti-virals by reference to 
 structural information\, illustrating this by our work especially on foot-
 and-mouth disease virus\, which is responsible for a terrible disease in l
 ivestock\, and the on the quite different viruses responsible for hand-foo
 t-and-mouth disease in humans\, currently endemic in South Asia. Attemptin
 g such a rational approach exposes the limits of our fundamental knowledge
  of how these viruses work\, and how the immune system controls viral infe
 ctions\, but I will try to show that it can also throw new light on these 
 fundamental questions.  
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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