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SUMMARY:Insights in the metabolic control of T cell migration and function
 : implications for immune inflammation in metabolic diseases - Dr Claudio 
 Mauro\, Queen Mary\, University of London
DTSTART:20130913T130000Z
DTEND:20130913T150000Z
UID:TALK46261@talks.cam.ac.uk
CONTACT:David Williamson
DESCRIPTION:Metabolic diseases\, including atherosclerosis\, obesity and d
 iabetes\, and arthritis are a leading cause of morbidity. Low-grade T cell
 -mediated inflammation is associated with these conditions and contributes
  to their pathogenesis and progression. Our current studies indicate that 
 interfering with metabolic pathways (i.e.\, lipid\, glucose and oxidative 
 metabolism) alters T cell trafficking and function in vitro and in vivo. T
 he major hypothesis we are investigating is that metabolic alterations lea
 d to aberrant T cell migration patterns\, which favour the establishment o
 f chronic inflammation. We are exploring the mechanisms of metabolic contr
 ol of T cell migration in physiology and under metabolic stress. We are al
 so investigating the effect of drugs that correct altered metabolism (e.g.
 \, the antidiabetic drug metformin) on T cell trafficking and inflammation
  in murine models of obesity. These studies will provide insights into the
  role of energy balance on physiologic T cell trafficking and the effect o
 f altering metabolism on the development of T cell-mediated inflammation.
LOCATION:Brain Repair Centre\, Forvie Site\, Robinson Way
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