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SUMMARY:Chronic Effects and Biological Upshots of Cannabis Use - Ronald Be
 rger\, Assistant Professor\, Whitaker Biomedical Engineering Institute\, S
 chool of Medicine\, Johns Hopkins University
DTSTART:20130725T090000Z
DTEND:20130725T103000Z
UID:TALK46405@talks.cam.ac.uk
CONTACT:Khaled O. Zimmermann
DESCRIPTION:Although there are over 300 cannabinoid or cannabinoid-related
  compounds\nreported as natural constituents of Cannabis (Turner\, et al.\
 , 1980) most strains\nof marihuana are characterized by the production of 
 a biogenetically related series of compounds (Figure 1). Cannabinoids are 
 terpenophenolic compounds believed\nto originate in the plant from condens
 ation of a terpene derivative (such as geranyl\npyrophosphate) with the ph
 enol olivetol (as olivetolic acid) to form the cannabinoid\nseries which i
 ncludes cannabigerolic acid (CBGA)\, cannabichromenic acid (CBCA)\, cannab
 idiolic acid (CBDA)\, and Δ^9^-tetrahydrocannabinolic acid (Δ^9^-THCA) (
 Mechoulam\, 1970\; Shoyama\, et al.\, 1975). These cannabinoids occur natu
 rally predominantly in their water-soluble acid forms but are readily deca
 rboxylated to their water-insoluble neutral forms by mild heating or dryin
 g of plant\ntissues or extracts.
LOCATION:Jock Colville Hall\, Churchill College\, University of Cambridge
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