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SUMMARY:Watching Individual Proteins Working on Single Molecules of DNA: f
 rom Biophysics to Cancer - Steve Kowalczykowski\, University of California
DTSTART:20130809T151500Z
DTEND:20130809T170000Z
UID:TALK46441@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:We can now watch individual proteins acting on single molecule
 s of DNA. Visualization is achieved by capturing a single DNA molecule wit
 h optical traps or by tethering to a glass surface. Proteins are visualize
 d via fluorescent reporters\, and molecules are manipulated using microflu
 idic flowcells. Using these approaches\, we have imaged proteins functioni
 ng in the homology-directed repair of DNA breaks. We can image the search 
 for DNA homology conducted by the RecA\, the self-assembly of RecA and RAD
 51 on DNA\, and the function of mediators such as RecFOR and BRCA2. 
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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