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SUMMARY:A systems view of recognition by the T cell receptor provides mult
 iple opportunities for rational therapeutic interventions in cancer\, infe
 ction and autoimmunity - Andrew Sewell\, University of Cardiff
DTSTART:20131122T130000Z
DTEND:20131122T140000Z
UID:TALK46496@talks.cam.ac.uk
CONTACT:Dr Tennie Videler
DESCRIPTION:Clonal selection theory proposed that individual T-cells are s
 pecific for a single peptide–MHC antigen. However\, the repertoire of al
 pha-beta T cell receptors (TCRs) is dwarfed by the vast array of potential
  foreign peptide–MHC complexes and a comprehensive system requires each 
 T-cell to recognize numerous peptides and thus be crossreactive. This comp
 romise on specificity has profound implications because the chance of any 
 ligand being an optimal fit for its cognate TCR is small as there will alm
 ost always be more potent agonists. Furthermore\, any TCR raised against a
  specific peptide–MHC in vivo can only be the best available solution fr
 om the naïve T-cell pool and is unlikely to be the best possible solution
  from the substantially greater number of TCRs that could theoretically be
  produced. This ‘systems view’ of TCR recognition allows multiple aven
 ues for manipulation of T-cell immunity. In this talk I hope to explore ho
 w enhanced T cell receptors and altered peptide [or non-peptide] TCR ligan
 ds can be used in immunotherapy.
LOCATION:Sackler Lecture Theater on level 7 of the CIMR (Cambridge Institu
 te for Medical Research)
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