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SUMMARY:Systems biology of stem cell fate - Ben MacArthur (University of S
 outhampton)
DTSTART:20140120T160000Z
DTEND:20140120T170000Z
UID:TALK46627@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:A number of recent studies using high-throughput single cell g
 ene expression profiling have uncovered a surprising degree of cell-to-cel
 l variability within apparently functionally homogeneous embryonic or indu
 ced pluripotent stem cell populations. Collectively\, these reports sugges
 t that both deterministic and stochastic mechanisms play key parts in plur
 ipotent stem cell identity. In this talk I will discuss some of the origin
 s and consequences of this cell-cell variability\, particularly focussing 
 on the role that feedback loops in the underlying transcriptional regulato
 ry circuitry have in controlling population variability. I will also outli
 ne a statistical view in which appropriately defined heterogeneity is a ce
 ntral feature of pluripotent stem cell populations.\n\nHosted by Florian M
 arkowetz
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
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