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SUMMARY:Single molecule approaches for studying gene expression in intact 
 mammalian tissues. - Shalev Itzkovitz (Weizmann Institute)
DTSTART:20140331T150000Z
DTEND:20140331T160000Z
UID:TALK46643@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Mammalian tissues are composed of heterogeneous cells\, intera
 cting in highly structured microenvironments to achieve physiologic goals.
  Understanding tissue complexity requires developing quantitative tools fo
 r examining single cells within the natural tissue microenvironment. Our l
 ab is developing approaches based on single molecule fluorescence in-situ 
 hybridization that enable reconstructing all phases of gene expression\, f
 rom chromatin states\, through transcription rates to mRNA degradation whi
 le preserving the intact tissue structure. I will describe applications of
  this approach for studying stem cell identity in intestinal crypts as wel
 l as single cell heterogeneity in the mammalian liver.\n\nHosted by Nitzan
  Rosenfeld.
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
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