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SUMMARY:Molecular imaging of tumor progression at the tumor/stromal bounda
 ry - Patricia Keely\, Associate Professor and Co-PI LOCI\, Madison-Wiscons
 in
DTSTART:20130902T110000Z
DTEND:20130902T120000Z
UID:TALK46971@talks.cam.ac.uk
CONTACT:Stefanie Reichelt
DESCRIPTION:Appropriate cellular interactions with the extracellular matri
 x (ECM) help to establish normal cellular architecture and differentiation
 . During oncogenic transformation\, these normal interactions with the ECM
  are profoundly altered\, resulting in cells that lose their polarization 
 and differentiation\, lose anchorage dependent growth control\, and acquir
 e a migratory\, invasive phenotype. Our lab is interested in understanding
 \, at a molecular level\, how cellular interactions with the ECM determine
  differentiation and epithelial polarization\, and how these interactions 
 are altered during carcinogenesis to result in invasive\, metastatic carci
 noma.
LOCATION:CRUK Cambridge Institute Lecture Theatre
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