BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Measuring within-tumour diversity as a universal biomarker for can
 cer prognosis - Trevor Graham (Barts Cancer Institute\, Queen Mary Univ Lo
 ndon)
DTSTART:20131111T160000Z
DTEND:20131111T170000Z
UID:TALK47007@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Carcinogenesis is fundamentally an evolutionary process\; esta
 blishing the prognosis for a cancer therefore requires predicting the futu
 re course of tumour evolution.  The same is true in premalignant condition
 s: the risk of developing cancer is determined by how the premalignant les
 ion is evolving.\n\nThe level of diversity within a population largely det
 ermines how fast that population will evolve. If there is no diversity nat
 ural selection cannot operate\, whereas diverse populations are likely to 
 contain well-adapted individuals that can prosper in changing environments
 .  Consequently\, quantification of within-tumour diversity is likely to b
 e a proxy-measure of the rate of the underlying evolutionary process that 
 drives carcinogenesis.\n\nIn this talk\, I will describe how we have measu
 red within-tumour diversity\, both genetically and phenotypically\, and us
 ed these measures to successfully determine prognosis in both established 
 cancers and in premalignant lesions.  I will focus particularly on lung ca
 ncer and the premalignant condition Barrett’s Oesophagus.  Building upon
  this work\, I will present the case for the quantification of within-tumo
 ur diversity as a universal biomarker for cancer prognosis.
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
END:VEVENT
END:VCALENDAR