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SUMMARY:Immune-metabolic interaction in Drosophila. - Dr Marc Dionne from 
 the Peter Gorer Dept of Immunobiology\, King's College London 
DTSTART:20131128T143000Z
DTEND:20131128T153000Z
UID:TALK47262@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Immune responses and metabolic regulation are intimately linke
 d in all animals. However\, our understanding of the mechanistic underpinn
 ings of this linkage is incomplete. I will present two different aspects o
 f metabolic-immune interaction in Drosophila. In the first part of the tal
 k\, I will present our recent data showing that the transcription factor M
 EF2 is a critical switch between immune function and metabolic storage. Fl
 ies lacking MEF2 in the fat body exhibit dramatic reductions in storage of
  triglyceride and glycogen and are simultaneously severely immunocompromis
 ed\; we have shown that these phenotypes reflect distinct transcriptional 
 functions of MEF2\, and that the loss of "metabolic" MEF2 contributes to t
 he loss of anabolic enzyme expression in Gram-negative bacterial infection
 . In the second part of the talk\, I will discuss the role of the Drosophi
 la cytokine upd3 in regulation of phagocyte bactericidal activity and cell
 ular lipid metabolism during mycobacterial infections.
LOCATION:Part II Room\, Department of Genetics
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