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SUMMARY:Dissecting genotype to phenotype relationships - Oliver Stegle (EM
 BL-European Bioinformatics Institute)
DTSTART:20131010T100000Z
DTEND:20131010T110000Z
UID:TALK47440@talks.cam.ac.uk
CONTACT:Zoubin Ghahramani
DESCRIPTION:Individuals differ in important phenotypes\, including the ris
 k to develop disease\, fitness or intelligence. Understanding the underlyi
 ng determinants of these phenotypic differences is a central aim of modern
  biology. For many phenotypes of interest\, is has been shown that genotyp
 e\, and variation in external environments as well as their interactions c
 ontribute to phenotype variability. Thanks to technological advances in ge
 nome-sequencing\, it is now possible to fit large-scale models to populati
 on-level data\, unraveling the genotype-to-phenotype map at an unprecedent
 ed resolution. In this talk\, I will discuss current statistical challenge
 s and opportunities in the genetic analyses of global phenotypes and molec
 ular traits. I will discuss suitable machine learning approaches and scala
 bility challenges of latent variable models. Finally\, I will conclude wit
 h an outlook of how causality regulatory relationships can be detected by 
 combining model comparison techniques with informative experimental design
 s.
LOCATION:Engineering Department\, CBL Room BE-438
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