BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:The UK10K Cohorts Project: Rare variant analysis by whole genome s
 equencing in 3\,621 samples - Klaudia Walter\, Sanger Institute
DTSTART:20140127T191500Z
DTEND:20140127T213000Z
UID:TALK47523@talks.cam.ac.uk
CONTACT:Peter Watson
DESCRIPTION:The UK10K Cohorts Project aims to research the relationship be
 tween rare and common genetic variants with a comprehensive set of quantit
 ative measures that \nare relevant to cardiovascular and metabolic disease
 . The project is based on two cohorts\, ALSPAC (Bristol) and TwinsUK (UK-w
 ide)\, in total 3\,621 individuals.\n \nSome of the challenges in this pro
 ject are to call genetic variants accurately from low-coverage data across
  thousands of samples and to impute missing and \nlow-quality variants. Th
 e loss of power poses another problem for association analyses with rare v
 ariants. On the other hand these rare variants allow in depth \nanalyses o
 f the population structure within the UK.\n \nThe whole UK10K project rece
 ived a £10.5 million funding award from the Wellcome Trust\, it is curren
 tly Britain’s largest genomic sequencing consortium (2010 to 2013). The 
 UK10K project also provides an enduring data resource for future research 
 into human genetics.
LOCATION:Statistical Laboratory\, University of Cambridge
END:VEVENT
END:VCALENDAR