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SUMMARY:Engineered Nanoparticles: the Bionano Interface in a Biological En
 vironment - Francesca Baldelli-Bombelli\, Department of Pharmacy\, Univers
 ity of East Anglia
DTSTART:20131101T140000Z
DTEND:20131101T150000Z
UID:TALK47956@talks.cam.ac.uk
CONTACT:Alessio Zaccone
DESCRIPTION:Nanomedicine is a new branch of medicine where nano-scaled mat
 erials are\nused for the detection and treatment of human diseases. It is 
 a growing\nmultidisciplinary area of research aiming to develop novel nano
 materials that\ncan combine diagnostic and therapeutic components in one u
 nique particle.\nHuge efforts have been done to better understand how the 
 physical-chemical\nproperties of nanoparticles (NPs) affect their interact
 ion with the cell. It is now\naccepted that NP surfaces in a biological en
 vironment are immediately\nmodified by the adsorption of proteins leading 
 to a protein “corona” defining\nthe biological identity of the particl
 e. For NPs of the same material differences\nin size and surface charge al
 ter the composition of the corona significantly.\nThis implies that extrem
 e care must be taken in the development of\nnanomedicine and nanotherapeut
 ics in terms of controlling the manufacturing\nprocess of nanoparticles an
 d control of the surface properties of the final\nproduct.\nHere\, differe
 nt approaches to functionalize the surface of nanoparticles\ndesigned for 
 biomedical applications are presented. A methodology to\naddress the diffe
 rent aspects governing the formation and the function of the\nprotein coro
 na in the biological environment is outlined. These data highlight\nthe im
 portance of this methodology as an analysis to be used in advance of\nthe 
 application of engineered NPs in biological environments.
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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