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SUMMARY:Systematic cell biology - Moving beyond text-book schemes - Maya S
 chuldiner\, The Weizmann Insitute of Science
DTSTART:20140109T140000Z
DTEND:20140109T150000Z
UID:TALK48305@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Cells are highly complex systems and as such require complex t
 ools to study. Indeed\, in the past years new tools have revolutionized ou
 r ability to move from the study of single genes to genomes and from singl
 e RNA molecules to global expression profiles. However\, the main mediator
 s of cellular function are proteins and therefore a true understanding of 
 how proteins mature and target to their site of function is an additional\
 , and essential\, layer for understanding cell biology at a molecular leve
 l. For many years the pathways for protein biogenesis were studied for sin
 gle proteins that were established as “model proteins” giving rise to 
 simplified textbook schemes of cellular function. Proteins that did not us
 e the known pathways were categorized as “exceptions to the rule” and 
 often the pathways mediating their maturation were never uncovered. \nIn t
 he talk I will discuss new tools for assessing the biogenetic requirements
  of organelle proteins in the cell by combining toolsets for systematic pr
 oteomic studies in Saccharomyces cerevisiae. These methods rely on the abi
 lity to rapidly generate tailor made collections of mutants and screen the
 m via a fully automated high content screening platform. This approach sho
 uld enable a new light to be shed on basic questions in cell biology\, thu
 s enabling a better understanding of the complex mechanisms that guide org
 anelle biology in yeast.\n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
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