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SUMMARY:Widespread translation of small Open Reading Frames from coding re
 gions\, UTRs and non-coding RNAs. - Professor Juan Pablo Couso\, School of
  Life Sciences\, University of Sussex 
DTSTART:20131121T143000Z
DTEND:20131121T153000Z
UID:TALK48850@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Thousands of small Open Reading Frames (smORFs) encoding small
  peptides of fewer than 100 amino-acids exist in our genomes. Examples of 
 functional smORFs have been characterised in a few species but the actual 
 number of translated smORFs\, and their molecular\, functional and evoluti
 onary features are not known. I will present a genome-wide assessment of s
 mORF translation by deep polysomal profiling suggesting that smORFs are tr
 anslated at the same level and in the same relative numbers (80%) as norma
 l proteins. The smORF peptides appear widely conserved\, show activity in 
 cells\, and display a putative amino-acid signature. These findings reinfo
 rce the idea that smORFs are an abundant and fundamental genome component\
 , displaying features usually attributed to canonical proteins\, including
  high translation levels\, biological function\, amino-acid sequence speci
 ficity and cross-species conservation.
LOCATION:Part II Room\, Department of Genetics
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