BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Bacterial Genomes and Metagenomes: from point mutations to public 
 health - Professor Mark Pallen\, Professor of Microbial Genomics and Head 
 of the Division of Microbiology and Infection
DTSTART:20140117T130000Z
DTEND:20140117T140000Z
UID:TALK48870@talks.cam.ac.uk
CONTACT:Lucy Lloyd
DESCRIPTION:High-throughput sequencing (HT) has transformed clinical micro
 biology in recent years. Several proof-of-principle studies have shown tha
 t whole-genome sequencing\, greatly facilitated by HTS\, is able to provid
 e a fine-grained view of the epidemiology of bacterial infections in the c
 ommunity and in hospitals\, showing how pathogens and virulence/resistance
  spread and evolve. I will describe our experiences with this approach on 
 Shiga-toxin-producing E. coli and the multi-drug resistant Gram-negative h
 ospital pathogen\, Acinetobacter baumannii. We have also been exploring th
 e diagnostic potential of shotgun metagenomics—that is the open-ended se
 quencing of DNA from mixtures of organisms without culture or capture of b
 acterial cells. I will show how this approach can be used to recover genom
 es of E. coli and M. tuberculosis from clinical and historical samples\, i
 ncluding retrospective diagnosis of tuberculosis in 18th Century Hungarian
  mummies.
LOCATION:Large Seminar Room\, 1st Floor\, Institute of Public Health\, Uni
 versity Forvie Site\, Robinson Way\, Cambridge
END:VEVENT
END:VCALENDAR