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SUMMARY:The Resistant Cancer Cell Line (RCCL) collection – cancer cell l
 ines with acquired drug resistance as a pre-clinical and basic science mod
 el - Martin Michaelis (University of Kent)
DTSTART:20140217T160000Z
DTEND:20140217T170000Z
UID:TALK49168@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:The heterogeneity and individuality of cancer diseases is trem
 endously high. Recent genomic investigations revealed a tremendous genetic
  complexity in the cells from solid cancer diseases. Cancer cell (sub)popu
 lations may differ substantially between primary tumours and metastases as
  well as within primary tumours. This heterogeneity is a consequence of ca
 ncer clonal evolution processes. Among other models\, comprehensive cancer
  cell line collections will be required to address this wide complexity.\n
 Resistance acquisition to anti-cancer therapies represents a major obstacl
 e to the development of effective anti-cancer therapies and contributes to
  cancer cell clonal evolution processes and heterogeneity. Major cancer ce
 ll drug resistance mechanisms have been discovered in drug-adapted cancer 
 cell lines including the ABC transporters ABCB1 (also known as P-glycoprot
 ein or MDR1) and ABCC1 (also known as MRP1) and clinically relevant resist
 ance mechanisms to so-called “targeted therapeutics” (e.g. EGFR tyrosi
 ne kinase inhibitors\, oncogenic BRAF inhibitors). The Resistant Cancer Ce
 ll Line (RCCL) collection (http://www.kent.ac.uk/stms/cmp/RCCL/RCCLabout.h
 tml) consists of approximately 1000 cell lines from 15 different cancer en
 tities with acquired resistance to a broad range of cytotoxic and targeted
  anti-cancer drugs. I will present an overview of our current projects on 
 the studying of drug-induced cancer cell resistance mechanisms\, the inves
 tigation of anti-cancer agents\, and the examination of drug-induced clona
 l evolution processes.\n
LOCATION:Cancer Research UK Cambridge Institute\, Lecture Theatre
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